Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC

The aim of this study is to develop a once-daily sustained release matrix tablet of ibuprofen using hydroxypropyl methylcellulose [HPMC] as release controlling factor and to evaluate drug release parameters as per various release kinetic models. In order to achieve required sustained release profile tablets were directly compressed using Avicel pH 101 and Magnesium stearate. The formulated tablets were also characterized by physical and chemical parameters and results were found in acceptable limits. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. Criteria for selecting the most appropriate model was based on linearity [coefficient of correlation]. The drug release data fit well to the Higuchi expression. Drug release mechanism was found as a complex mixture of diffusion, swelling and erosion

Post surgical wound infections: a study on threats of emerging resistance

300 bacterial isolates associated with post surgical wound infections were tested in vitro for their sensitivity/resistance pattern against 20 antibacterial agents. The study indicated that the bacteria in which clinically significant resistance has now become a potential problem include Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Proteus. Klebsiella, Staphylococcus epidermidis, Enterobacter and Citrobacter species. Among the tested drugs the percent resistance rate observed were tobramycin [9.75%], amikacin [10.03%], enoxacin [20.53%], ofloxacin [25.93%], ciprofloxacin [26.27%], gentamicin [29.03%], ceftrioxone [36%], aztreonam [41.07%], cefaclor [44.07%]. The conclusion from the study can be drawn that tobramycin and amikacin [aminoglycosides] and enoxacin, ciprofloxacin and ofloxacin [Fluoroquinolones] are very effective agents for treating post surgical wound infections. However resistance to these agents is rapidly increasing